{"id":976,"date":"2022-08-24T16:48:01","date_gmt":"2022-08-24T07:48:01","guid":{"rendered":"https:\/\/ojima-dental.com\/blog\/?p=976"},"modified":"2024-08-04T16:51:46","modified_gmt":"2024-08-04T07:51:46","slug":"%e3%81%8c%e3%82%93%e3%81%b0%e3%82%8ccortexyme%e7%a4%be%ef%bc%81%ef%bc%81","status":"publish","type":"post","link":"https:\/\/ojima-dental.com\/blog\/?p=976","title":{"rendered":"\u304c\u3093\u3070\u308cCortexyme\u793e\uff01\uff01"},"content":{"rendered":"\n<p>2019\u5e741\u6708\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u88fd\u85ac\u4f1a\u793eCortexyme\u304b\u3089 Science Advances \u306b\u3001\u6b21\u306e\u3088\u3046\u306a\u9a5a\u304f\u3079\u304d\u8ad6\u6587\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p> \u300cPorphyromonas gingivalis in Alzheimer\u2019s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors \uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8133\u5185\u306b\u5b58\u5728\u3059\u308bP.gingivalis\uff1a\u75c5\u6c17\u306e\u539f\u56e0\u3092\u793a\u3059\u8a3c\u62e0\u3068\u5c0f\u5206\u5b50\u3092\u7528\u3044\u305f\u6cbb\u7642\uff09\u300d <\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p> \u3053\u308c\u306f\u3001\u6b6f\u5468\u75c5\u306e\u6700\u3082\u91cd\u8981\u306akey\u3068\u306a\u308b\u83cc\u3001P.gingivalis\u304c\u5206\u6ccc\u3059\u308b\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u9175\u7d20gingipain \u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3001\u305d\u3057\u3066\u305d\u308c\u3092\u6a19\u7684\u306b\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6cbb\u7642\u304c\u53ef\u80fd\u306b\u306a\u308b\u3002\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p> P.gingivalis \uff08Pg\u83cc\uff09\u306f\u3001\u3084\u306f\u308a\u91cd\u5ea6\u306b\u306a\u308c\u3070\u305d\u306e\u53e3\u8154\u5185\u3067\u306e\u5272\u5408\u3082\u591a\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u52ff\u8ad6\u3001\u8a8d\u77e5\u75c7\u306e\u539f\u56e0\u304c100\uff05Pg\u83cc\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u8a8d\u77e5\u75c7\u4e88\u9632\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u3082\u6b6f\u5468\u75c5\u3092\u4e88\u9632\u3057\u3066\u3044\u304f\u4e8b\u306e\u91cd\u8981\u6027\u304c\u660e\u78ba\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p> \u80c3\u304c\u3093\u3068\u30d4\u30ed\u30ea\u83cc\u306e\u95a2\u9023\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u6642\u306e\u3088\u3046\u306b\u3082\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p> Cortexyme \u793e\u306f\u3001\u3059\u3067\u306b gingipain \u963b\u5bb3\u85ac\u3092\u958b\u767a\u3057\u3066\u304a\u308a\u3001\u3044\u304f\u3064\u304b\u81e8\u5e8a\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8a8d\u77e5\u75c7\u306e\u70ba\u306b\u3082\u3001\u305d\u3057\u3066\u6b6f\u5468\u75c5\u306e\u70ba\u306b\u3082\u3001\u305c\u3072Cortexyme\u793e\u306b\u306f\u9811\u5f35\u3063\u3066\u3001\u753b\u671f\u7684\u306a gingipain \u963b\u5bb3\u85ac \u3092\u671f\u5f85\u3057\u305f\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" loading=\"lazy\" width=\"490\" height=\"340\" src=\"https:\/\/ojima-dental.com\/blog\/wp-content\/uploads\/2022\/08\/\u8133.jpeg\" alt=\"\" class=\"wp-image-1004\" srcset=\"https:\/\/ojima-dental.com\/blog\/wp-content\/uploads\/2022\/08\/\u8133.jpeg 490w, https:\/\/ojima-dental.com\/blog\/wp-content\/uploads\/2022\/08\/\u8133-300x208.jpeg 300w\" sizes=\"(max-width: 490px) 85vw, 490px\" \/><\/figure>\n\n\n\n<p>\u6b6f\u79d1\u885b\u751f\u58eb\u3000\u9ad8\u6a4b\u3000\u6075<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2019\u5e741\u6708\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u88fd\u85ac\u4f1a\u793eCortexyme\u304b\u3089 Science Advances \u306b\u3001\u6b21\u306e\u3088\u3046\u306a\u9a5a\u304f\u3079\u304d\u8ad6\u6587\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002 \u300cPorphyromonas gingivalis in Alzheimer\u2019s d &hellip; <a href=\"https:\/\/ojima-dental.com\/blog\/?p=976\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;\u304c\u3093\u3070\u308cCortexyme\u793e\uff01\uff01&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/976"}],"collection":[{"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=976"}],"version-history":[{"count":9,"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/976\/revisions"}],"predecessor-version":[{"id":1006,"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=\/wp\/v2\/posts\/976\/revisions\/1006"}],"wp:attachment":[{"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ojima-dental.com\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}